January 1, 2007Physiological ResearchOpen Access

Spironolactone differently influences remodeling of the left ventricle and aorta in L-NAME-induced hypertension

View Full Paper

Ask AI

Bookmark

Population

Rats with N(G)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension

Comparison

Spironolactone combined with L-NAME for 5 weeks vs L-NAME alone, spironolactone alone, and control…

Design

Preclinical

Follow-up

5 weeks

Authors

FŠFedor Šimko JMJana Matusková ILIvan Luptak

Discussion

Member takes

Overview

Hypothesis-generating for tissue-specific effects of spironolactone in NO-deficient hypertension; requires clinical validation before any practice consideration.

Structured PICO

Population

Rats with N(G)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension

Intervention

Spironolactone (200 mg/kg) combined with L-NAME (40 mg/kg) for 5 weeks

Comparator

L-NAME (40 mg/kg) alone, spironolactone (200 mg/kg) alone, and control group

Outcome

Development of hypertension, tissue nitric oxide synthase activity, and left ventricular (LV) and aortic remodelingsurrogate

In a rat model of NO-deficient hypertension, spironolactone partially prevents hypertension and left ventricular hypertrophy but does not prevent aortic remodeling, suggesting different mechanisms of reactive growth.

Cite This Study

Šimko et al. (2007) studied this question.

synapsesocial.com/papers/6a90d847d2f2d69b3a74472d https://doi.org/10.33549/physiolres.931394

View Full Paper

Ask AI

Bookmark

January 1, 2007Physiological ResearchOpen Access

Spironolactone differently influences remodeling of the left ventricle and aorta in L-NAME-induced hypertension

View Full Paper

Ask AI

Bookmark

Population

Rats with N(G)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension

Comparison

Spironolactone combined with L-NAME for 5 weeks vs L-NAME alone, spironolactone alone, and control…

Design

Preclinical

Follow-up

5 weeks

Authors

FŠFedor Šimko JMJana Matusková ILIvan Luptak

Discussion

Member takes

Overview

Hypothesis-generating for tissue-specific effects of spironolactone in NO-deficient hypertension; requires clinical validation before any practice consideration.

Structured PICO

Population

Rats with N(G)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension

Intervention

Spironolactone (200 mg/kg) combined with L-NAME (40 mg/kg) for 5 weeks

Comparator

L-NAME (40 mg/kg) alone, spironolactone (200 mg/kg) alone, and control group

Outcome

Development of hypertension, tissue nitric oxide synthase activity, and left ventricular (LV) and aortic remodelingsurrogate

Cite This Study

Šimko et al. (2007) studied this question.

synapsesocial.com/papers/6a90d847d2f2d69b3a74472d https://doi.org/10.33549/physiolres.931394

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark