Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1995Cardiovascular Research

Effects of nitric oxide synthase inhibition on the muscle blood flow response to exercise in rats with heart failure

View Full Paper
Ask AI
Bookmark
Share

Population

23 conscious rats, including those with chronic heart failure due to myocardial infarction and sham-operated…

Comparison

NG-nitro-L-arginine methyl ester 20 mg/kg… vs Sham-operated rats and rats with small MI; also…

Design

Preclinical

Authors

THToshinori HiraiRZRobert ZelisTMTimothy I. Musch

Discussion

Loading...

Member takes

Overview

Attenuated NO contribution to skeletal muscle hyperemia in large-MI rat models; leaves open translation to human HF and therapeutic relevance.

Structured PICO

P
Population
23 conscious rats, including those with chronic heart failure (CHF) due to myocardial infarction (large MI, n=8; small MI, n=5) and sham-operated controls (n=10).
I
Intervention
NG-nitro-L-arginine methyl ester (L-NAME) 20 mg/kg intra-arterial (i.a.)
C
Comparator
Sham-operated rats and rats with small MI; also compared to pre-L-NAME baseline
O
Outcome
Blood flow to the hindquarter musculature during exercise (4 min of treadmill running) measured with radiolabelled microspheressurrogate

The contribution of the nitric oxide pathway to exercise-induced hyperemia in skeletal muscle is attenuated in rats with chronic heart failure.

Cite This Study

Hirai et al. (1995) studied this question.

synapsesocial.com/papers/6a797f1fe357fbdac58911e7https://doi.org/10.1016/s0008-6363(95)00068-2
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of NO synthase inhibition on the muscular blood flow response to treadmill exercise in rats1994 · 200 citations
  2. 2Effects of nitrite infusion on skeletal muscle vascular control during exercise in rats with chronic heart failure2015 · 24 citations
  3. 3Dietary nitrate supplementation: impact on skeletal muscle vascular control in exercising rats with chronic heart failure2016 · 45 citations
  4. 4Role of nitric oxide in mediating cardiovascular alterations accompanying heart failure in rats2004 · 10 citations
  5. 5Skeletal Muscle Vascular Control During Exercise2015 · 25 citations