Key result
Sodium nitrite infusion significantly reduced mean arterial pressure (136 vs 157 mm Hg, P<0.03) and increased vascular conductance during exercise in rats with NOS blockade.
Why the study?
Does sodium nitrite infusion reduce mean arterial pressure and increase skeletal muscle blood flow and vascular conductance during exercise in a rat model of NOS blockade?
Population
Male Sprague-Dawley rats (3-6 months, n=8) undergoing NOS blockade via L-NAME (10 mg/kg)
Comparison
Sodium nitrite infusion during submaximal… vs L-NAME alone and a published control data set of…
Design
Preclinical
Authors
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May support nitrite in NOS-impaired exercise; hypothesis-generating for human translation.
Does sodium nitrite infusion reduce mean arterial pressure and increase skeletal muscle blood flow and vascular conductance during exercise in a rat model of NOS blockade?
Absolute Event Rate: 136% vs 157%
p-value: p=<0.03
In a rat model of NOS blockade, sodium nitrite infusion reduced mean arterial pressure and improved vascular conductance during exercise, suggesting potential therapeutic applications for conditions with impaired NOS activity.
Ferguson et al. (2015) studied NOS blockade during exercise (n=19). Sodium nitrite (NO2 (-)) infusion vs. L-NAME alone was evaluated on Mean arterial pressure (MAP) (p=<0.03). Sodium nitrite infusion significantly reduced mean arterial pressure (136 vs 157 mm Hg, P<0.03) and increased vascular conductance during exercise in rats with NOS blockade.
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