Key result
Nitrite infusion increased total hindlimb skeletal muscle vascular conductance during exercise in rats with chronic heart failure (0.93 vs 0.85 ml·min(-1)·100 g(-1)·mmHg(-1); P<0.05).
Why the study?
Does nitrite infusion improve skeletal muscle blood flow and vascular conductance during exercise in rats with chronic heart failure?
Population
Adult male Sprague-Dawley rats with moderate chronic heart failure induced by coronary artery ligation.
Comparison
Nitrite infusion during treadmill exercise. vs Treadmill exercise without NO2- infusion.
Design
Preclinical
Authors
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Should not change HF practice; extends preclinical evidence for nitrite during exercise.
Does nitrite infusion improve skeletal muscle blood flow and vascular conductance during exercise in rats with chronic heart failure?
Absolute Event Rate: 0.93% vs 0.85%
p-value: p=<0.05
Nitrite infusion augments skeletal muscle vascular conductance during exercise in a rat model of chronic heart failure, suggesting a potential targeted therapy for vascular dysfunction in CHF.
Glean et al. (2015) studied Chronic heart failure. Nitrite (NO2-) infusion vs. Without NO2- infusion was evaluated on Total hindlimb skeletal muscle vascular conductance (VC) (p=<0.05). Nitrite infusion increased total hindlimb skeletal muscle vascular conductance during exercise in rats with chronic heart failure (0.93 vs 0.85 ml·min(-1)·100 g(-1)·mmHg(-1); P<0.05).
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