Why the study?
Does dietary nitrate supplementation improve skeletal muscle blood flow and vascular conductance during exercise in rats with chronic heart failure?
Population
20 young adult male Sprague-Dawley rats with chronic heart failure induced by myocardial infarction via…
Comparison
Dietary nitrate supplementation via NO3--rich… vs NO3--depleted placebo beetroot juice diluted in…
Design
Preclinical, Rats were assigned randomly, placebo-controlled
Follow-up
5 days
Authors
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Does not support clinical nitrate use in heart failure; leaves open translation of rat muscle perfusion gains to humans.
Does dietary nitrate supplementation improve skeletal muscle blood flow and vascular conductance during exercise in rats with chronic heart failure?
Dietary nitrate supplementation via beetroot juice significantly increases skeletal muscle blood flow and vascular conductance during exercise in a rat model of chronic heart failure.
Ferguson et al. (2016) studied this question.
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