Why the study?
Does NOS inhibition during exercise reduce hindlimb muscle blood flow and vascular conductance in rats?
Population
17 adult female Wistar rats (age 3-4 months, body weight 257 ± 5 g).
Comparison
L-NAME administered during submaximal treadmill… vs Control exercise bout before L-NAME…
Design
Preclinical, Animals were randomly assigned to either an experimental or time…
Follow-up
Acute (during exercise bout)
Authors
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Does not inform clinical practice; confirms nitric oxide's role in rat exercise hyperemia but leaves human translation open.
Does NOS inhibition during exercise reduce hindlimb muscle blood flow and vascular conductance in rats?
Nitric oxide is a quantitatively important regulator of exercise hyperemia in locomotory muscles during submaximal whole-body exercise, and its fiber-type dependency is altered when NOS inhibition occurs during versus prior to exercise.
Copp et al. (2009) studied this question.
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