Key result
Selective nNOS inhibition with SMTC reduced total hindlimb skeletal muscle blood flow (204 vs 241 ml min-1 (100 g)-1, P<0.05) and vascular conductance during high-speed treadmill running in rats.
Why the study?
Does selective nNOS inhibition reduce skeletal muscle blood flow and vascular conductance in rats during high-speed treadmill running?
Population
Rats (n=6) performing high-speed treadmill runs to exhaustion
Comparison
Selective nNOS inhibition with… vs Before SMTC administration (control)
Design
Preclinical
Authors
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May implicate nNOS in rat muscle hyperemia during intense exercise; leaves open translation to human cardiovascular physiology.
Does selective nNOS inhibition reduce skeletal muscle blood flow and vascular conductance in rats during high-speed treadmill running?
Absolute Event Rate: 204% vs 241%
p-value: p=<0.05
Selective nNOS inhibition reduces skeletal muscle blood flow and vascular conductance primarily in glycolytic fast-twitch muscle during high-speed running in rats.
Copp et al. (2013) studied Healthy (exercise physiology) (n=6). S-methyl-l-thiocitrulline (SMTC) vs. Control (before SMTC) was evaluated on Total hindlimb skeletal muscle blood flow during high-speed running (ml min-1 (100 g)-1) (p=<0.05). Selective nNOS inhibition with SMTC reduced total hindlimb skeletal muscle blood flow (204 vs 241 ml min-1 (100 g)-1, P<0.05) and vascular conductance during high-speed treadmill running in rats.
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