Key result
In conscious rats, SMTC produced a short-lived pressor effect and vasoconstriction, with cardiovascular effects at low doses consistent with nNOS inhibition, differing from the nonselective L-NAME.
Population
Conscious, male Sprague-Dawley rats
Comparison
S-methyl-L-thiocitrulline administered as 0.3… vs N-nitro-L-arginine methyl ester administered at…
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open whether selective nNOS inhibition offers distinct cardiovascular benefits in humans.
The distinct regional haemodynamic profile of low-dose SMTC compared to L-NAME in conscious rats is consistent with selective nNOS inhibition.
Wakefield et al. (2003) studied this question. S-methyl-L-thiocitrulline (SMTC) vs. N(G)-nitro-L-arginine methyl ester (L-NAME) was evaluated on Regional haemodynamic effects (blood pressure, heart rate, vascular conductance). In conscious rats, SMTC produced a short-lived pressor effect and vasoconstriction, with cardiovascular effects at low doses consistent with nNOS inhibition, differing from the nonselective L-NAME.
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