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January 1, 1994British Journal of PharmacologyOpen Access

The effects of perfusion rate and NG‐nitro‐L‐arginine methyl ester on cirazoline‐ and KCl‐induced responses in the perfused mesenteric arterial bed of rats

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Population

Isolated, perfused mesenteric arterial beds from normotensive and spontaneously hypertensive rats

Comparison

NG-nitro-L-arginine methyl ester in… vs Control conditions (absence of L-NAME) or D-NAME

Design

Preclinical

Authors

AAAyotunde S.O. AdeagboMemorial University of NewfoundlandRTReza TabrizchiMemorial University of NewfoundlandCTChris R. TriggleVascular / Pulmonary Vascular

Discussion

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Implication

Preserved NO synthase activity in hypertensive rat vessels; leaves open relevance to human hypertension.

Structured PICO

P
Population
Isolated, perfused mesenteric arterial beds from normotensive (Sprague Dawley, Wistar Kyoto) and spontaneously hypertensive rats
I
Intervention
NG-nitro-L-arginine methyl ester (L-NAME) in concentrations up to 100 microM
C
Comparator
Control conditions (absence of L-NAME) or D-NAME
O
Outcome
Perfusion rate/pressure relations and pressor responses to cirazoline and KClsurrogate

The study demonstrates that L-NAME potentiates vasoconstriction by inhibiting NO synthases and suggests that NO synthase activity is not impaired in the mesenteric arterial beds of spontaneously hypertensive rats.

Cite This Study

Adeagbo et al. (1994) studied this question.

synapsesocial.com/papers/6a83fadbbe1bfc07a3fe1691https://doi.org/10.1111/j.1476-5381.1994.tb14017.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased Endothelium-dependent Relaxation in New Zealand Genetic Hypertensive Rats1984 · 184 citations
  2. 2l ‐Arginine induces relaxation of rat aorta possibly through non‐endothelial nitric oxide formation1991 · 39 citations
  3. 3Activation of endothelial L-arginine pathway in resistance arteries. Effect of age and hypertension.1990 · 254 citations
  4. 4Role of endothelium-derived nitric oxide in the regulation of blood pressure.1989 · 1,838 citations
  5. 5NG-methylarginine, and inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo?1989 · 432 citations