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January 2, 1994Fundamental and Clinical Pharmacology

Involvement of endothelium‐derived NO in the basal tone and in the vasodilator responses to muscarinic agonists in the rat isolated mesenteric arterial bed

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Population

Rat isolated mesenteric vascular beds

Comparison

Infusion of NO-cyclic GMP pathway inhibitors and… vs Control conditions

Design

Preclinical

Authors

ABAL Muccillo BaischJLJ LarrueJFJL Freslon

Discussion

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Overview

Does not support NO as primary basal tone regulator; leaves open endothelium-derived NO dependence in sustained muscarinic vasodilation.

Structured PICO

P
Population
Rat isolated mesenteric vascular beds
I
Intervention
Infusion of NO-cyclic GMP pathway inhibitors (L-NOARG, L-NAME, methylene blue, water) and muscarinic agonists (acetylcholine, carbachol, oxotremorine, McNeil A 343)
C
Comparator
Control conditions (e.g., without L-NAME or water infusion)
O
Outcome
Changes in resting perfusion pressure and vasodilator responses (drop in perfusion pressure and area under the pressure trace)surrogate

In the rat mesenteric arterial bed, basal tone is controlled by factors other than NO, while the late sustained phase of muscarinic vasodilation relies on de novo synthesis of endothelium-derived NO.

Cite This Study

Baisch et al. (1994) studied this question.

synapsesocial.com/papers/6a8a7c60af65c378f7fd4e7bhttps://doi.org/10.1111/j.1472-8206.1994.tb00779.x
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Also Consider

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