Key result
High perfusion flow in rat mesenteric arterial beds increased perfusion pressure and stimulated the release of NO and ET-1, demonstrating that vascular tone is regulated by interacting endothelium-derived factors.
Population
Male Wistar rats aged 18 weeks (isolated mesenteric arterial bed preparation)
Comparison
Gradually increasing perfusion flow rates to… vs Low flow rate (5 ml/min) or untreated beds
Design
Preclinical
Authors
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Rat data implicate NO-ET-1 interplay in flow-mediated mesenteric tone; leaves open translation to human endothelial dysfunction.
Flow-induced changes in vascular tone in the rat mesenteric arterial bed are subtly regulated by the interaction of endothelium-derived factors including NO, EDHF, and ET-1.
Matsumoto et al. (2004) studied Healthy (animal model). High perfusion flow rate vs. Low perfusion flow rate (5 ml/min) was evaluated on Perfusion pressure and release of endothelium-derived factors (ET-1, NO). High perfusion flow in rat mesenteric arterial beds increased perfusion pressure and stimulated the release of NO and ET-1, demonstrating that vascular tone is regulated by interacting endothelium-derived factors.
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