Why the study?
Does endothelium removal or nitric oxide inhibition alter flow-dependent vasomotor tone in spontaneously hypertensive rats compared to normotensive rats?
Population
Normotensive Wistar-Kyoto and spontaneously hypertensive rats (in situ model of perfused mesenteric artery)
Comparison
Local inhibition of nitric oxide synthesis by… vs Control conditions
Design
Preclinical
Authors
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Endothelial impairment in hypertensive rat arteries; leaves open translation to human hypertension mechanisms.
Does endothelium removal or nitric oxide inhibition alter flow-dependent vasomotor tone in spontaneously hypertensive rats compared to normotensive rats?
Endothelium-dependent flow-induced vasodilation is impaired in conductance mesenteric arteries of spontaneously hypertensive rats compared to normotensive rats.
Qiu et al. (1994) studied this question.
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