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January 1, 1997The Japanese Journal of PharmacologyOpen Access

Flow-Dependent Regulation of Nitric Oxide Formation in the Isolated Canine Mesenteric Arterial Bed

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Population

Isolated canine mesenteric arterial bed preparations

Comparison

Stepwise increases in flow rate with or without… vs Control conditions

Design

Preclinical

Authors

TNTsutomu NakaharaKIKunio IshiiYTYoshio Tanaka

Discussion

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Overview

Shear stress may regulate BP via endothelial NO in resistance arteries; hypothesis-generating for human hypertension mechanisms.

Structured PICO

P
Population
Isolated canine mesenteric arterial bed preparations
I
Intervention
Stepwise increases in flow rate (8 to 40 ml/min) with or without N G-nitro-L-arginine (L-NNA, 100 μM) and Sodium nitroprusside (SNP, 0.1-10 μM)
C
Comparator
Control conditions (baseline flow rates without L-NNA or SNP)
O
Outcome
Perfusion pressure and cyclic GMP productionsurrogate

Increased flow rate stimulates nitric oxide formation in endothelial cells of resistance arteries, suggesting a role in regulating systemic blood pressure.

Cite This Study

Nakahara et al. (1997) studied this question.

synapsesocial.com/papers/6a880d0bb0d802598bf4d21ehttps://doi.org/10.1016/s0021-5198(19)31386-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Flow-Dependent Regulation of Nitric Oxide Formation in the IsolatedCanine Mesenteric Arterial Bed.1997 · 5 citations
  2. 2Flow-induced endothelium-dependent vasoreactivity in rat mesenteric arterial bed2004 · 9 citations
  3. 3Release of endothelium derived nitric oxide in relation to pressure and flow1991 · 95 citations
  4. 4Involvement of endothelium‐derived NO in the basal tone and in the vasodilator responses to muscarinic agonists in the rat isolated mesenteric arterial bed1994 · 4 citations
  5. 5Pulsatile flow enhances endothelium-derived nitric oxide release in the peripheral vasculature2000 · 108 citations