What question did this study set out to answer?

This study aims to evaluate the safety of newly developed radiopaque markers for measuring colonic transit time in chronic constipation.

May 9, 2026Journal of Smooth Muscle ResearchOpen Access

Colonic transit study in patients with chronic constipation using Japanese-made radiopaque markers

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Authors

TKTakeshi KAMIYANagoya City University EKEiji KubotaNagoya City University KOKeiji OzekiNagoya City University

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Implication

Randomized trial ensures safety of domestically produced radiopaque markers in patients with chronic constipation, indicating potential for future clinical use.

Key Points

This study aims to evaluate the safety of newly developed radiopaque markers for measuring colonic transit time in chronic constipation.
Five patients with chronic constipation ingested 24 radiopaque markers in gelatin capsules on Day 1.
A single abdominal radiograph was taken on Day 5 to count the markers remaining in the abdomen.
No adverse effects related to the markers were observed during the study.
No marker-related adverse effects were reported, confirming the safety of the radiopaque markers.
Among five patients, only one had a residual marker visible in the abdominal radiograph after five days.
The safety of the domestically produced markers is acceptable, suggesting further studies are needed.

Cite This Study

KAMIYA et al. (2026) studied this question.

synapsesocial.com/papers/69fed10fb9154b0b82878338 https://doi.org/10.1540/jsmr.62.17

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Implication

Randomized trial ensures safety of domestically produced radiopaque markers in patients with chronic constipation, indicating potential for future clinical use.

Colonic transit study in patients with chronic constipation using Japanese-made radiopaque markers

Discussion

Member takes

Implication

Key Points

Cite This Study

Colonic transit study in patients with chronic constipation using Japanese-made radiopaque markers

Discussion

Member takes

Implication

Key Points

Cite This Study

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