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September 1, 2002British Journal of PharmacologyOpen Access

Endothelial nitric oxide modulates perivascular sensory neurotransmission in the rat isolated mesenteric arterial bed

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Population

Rat isolated mesenteric arterial bed and thoracic aortic rings

Comparison

Nitric oxide synthase inhibitors, NO donor, and… vs Control conditions

Design

Preclinical

Authors

VRVera RalevicUniversity of Nottingham

Discussion

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Implication

Animal data suggest endothelial NO may inhibit sensory vasorelaxation; leaves open human relevance and precludes practice change.

Structured PICO

P
Population
Rat isolated mesenteric arterial bed and thoracic aortic rings
I
Intervention
Nitric oxide synthase (NOS) inhibitors (L-NAME, 7-NI), NO donor (SNP), and endothelial removal
C
Comparator
Control conditions (absence of inhibitors, intact endothelium)
O
Outcome
Vasorelaxation in response to electrical field stimulation (EFS) and pharmacological agentssurrogate

Endothelial nitric oxide acts as a prejunctional modulator to attenuate capsaicin-sensitive sensory neurotransmission in rat mesenteric arteries.

Cite This Study

Vera Ralevic (2002) studied this question.

synapsesocial.com/papers/6a7de5a30631e052c4b87cd6https://doi.org/10.1038/sj.bjp.0704837
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Release of Norepinephrine From Adrenergic Nerve Endings of Blood Vessels Is Modulated by Endothelium-Derived Relaxing Factor1990 · 75 citations
  2. 2Effects of NG‐substituted analogues of l ‐arginine on NANC relaxation of the rat anococcygeus and bovine retractor penis muscles and the bovine penile artery1991 · 72 citations
  3. 3Potent and Selective Inhibition of Neuronal Nitric Oxide Synthase by Nω-Propyl- l -arginine1997 · 193 citations
  4. 4Activation and Recovery of the PGE2-Mediated Sensitization of the Capsaicin Response in Rat Sensory Neurons1997 · 73 citations
  5. 5A capsaicin‐sensitive inhibitory reflex from the colon to mesenteric arteries in the guinea‐pig.1992 · 23 citations