Population
Rat isolated caudal artery (endothelium-intact and endothelium-denuded)
Comparison
Nitric oxide synthase inhibitors, haemoglobin… vs Control conditions and endothelium-denuded vs…
Design
Preclinical
Authors
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No immediate clinical implications from rat artery data; leaves open translation of endothelial NO effects to human vascular disease.
Endothelial nitric oxide acts as a functional antagonist to oppose vasoconstriction in the rat caudal artery by decreasing smooth muscle contractility.
Vo et al. (1992) studied this question.
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