Population
Anaesthetized, spontaneously hypertensive rats in which autonomic reflexes were abolished by ganglion blockade
Comparison
Endothelin-1 during infusion of NO synthase… vs Animals infused with phenylephrine to mimic…
Design
Preclinical
Authors
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NO mediates part of ET-1 vasodilation in hypertensive rats; leaves open the major NO-independent pathway and any clinical relevance.
Nitric oxide mediates a significant component of the vasodilator effect of endothelin-1 in spontaneously hypertensive rats, though a major component is NO-independent.
Fozard et al. (1992) studied this question.
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