What does this research mean for the field?

Inhibition of nitric oxide synthesis attenuates the vasodepressor response and significantly potentiates the pressor response to endothelin-1, demonstrating that endogenous nitric oxide modulates the vascular and permeability effects of endothelin-1. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

November 1, 1993British Journal of PharmacologyOpen Access

Vascular responses to endothelin‐1 following inhibition of nitric oxide synthesis in the conscious rat

Q: What is the clinical evidence from this study?

Study design: Other. Population: Healthy conscious rats. Intervention: NO synthesis inhibitors (L-NMMA or L-NAME) and ET-1 vs. Noradrenaline infusion. Primary outcome: Mean arterial blood pressure and microvascular permeability.

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Key result

Inhibition of nitric oxide synthesis with L-NMMA or L-NAME attenuated the vasodepressor response by ~40% and potentiated the pressor response to ET-1 by 100-180% in conscious rats.

Why the study?

Does inhibition of nitric oxide synthesis alter the effects of endothelin-1 on blood pressure and microvascular permeability in conscious rats?

Population

Conscious rats

Comparison

Intravenous administration of NO synthesis… vs Noradrenaline infusion followed by endothelin-1…

Design

Preclinical

Authors

JFJános G. FilepVascular Medicine ÉFÉva Földes‐FilepHôpital Maisonneuve-Rosemont ARAnne RousseauCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

Endogenous NO modulates ET-1 hemodynamic effects in rats; hypothesis-generating for human endothelial regulation.

Structured PICO

Does inhibition of nitric oxide synthesis alter the effects of endothelin-1 on blood pressure and microvascular permeability in conscious rats?

Population

Conscious rats

Intervention

Intravenous administration of NO synthesis inhibitors (L-NMMA 25 mg/kg or L-NAME 2 mg/kg) followed by endothelin-1 (1 nmol/kg)

Comparator

Noradrenaline infusion (620-820 ng/kg/min) followed by endothelin-1, or L-NAME + L-arginine/D-arginine

Outcome

Mean arterial blood pressure (MABP) and microvascular permeability (measured by extravasation of Evans blue dye)surrogate

Endogenous nitric oxide partially mediates the vasodepressor effect, attenuates the vasopressor action, and modulates the microvascular permeability effects of endothelin-1 in conscious rats.

Cite This Study

Filep et al. (1993) studied Healthy conscious rats. NO synthesis inhibitors (L-NMMA or L-NAME) and ET-1 vs. Noradrenaline infusion was evaluated on Mean arterial blood pressure and microvascular permeability. Inhibition of nitric oxide synthesis with L-NMMA or L-NAME attenuated the vasodepressor response by ~40% and potentiated the pressor response to ET-1 by 100-180% in conscious rats.

synapsesocial.com/papers/6a153eb7cb801b7f954e42e2 https://doi.org/10.1111/j.1476-5381.1993.tb13944.x

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Vascular responses to endothelin‐1 following inhibition of nitric oxide synthesis in the conscious rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vascular responses to endothelin‐1 following inhibition of nitric oxide synthesis in the conscious rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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