Why the study?
Does sympathetic nerve stimulation increase lung vascular permeability in rats?
Population
Isolated rat sympathetic nerve-lung preparation (normal, reserpinized, and capsaicin-treated rats)
Comparison
Sympathetic nerve stimulation vs Unstimulated state or pharmacologically blocked…
Design
Preclinical
Authors
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Sympathetic stimulation may increase rat lung vascular permeability via adrenergic and capsaicin-sensitive pathways; leaves open translation to human pulmonary edema.
Does sympathetic nerve stimulation increase lung vascular permeability in rats?
Sympathetic nerve stimulation increases lung vascular permeability in rats, an effect that appears to be mediated by adrenergic and capsaicin-sensitive mechanisms.
Sakakibara et al. (1992) studied this question.
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