Why the study?
Does sympathetic nerve stimulation affect pulmonary vascular tone via specific adrenoceptors in a feline model?
Population
Feline pulmonary vascular bed model
Comparison
Sympathetic nerve stimulation with and without… vs Baseline responses without antagonists or…
Design
Preclinical
Authors
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Warrants caution against clinical extrapolation; leaves open adrenoceptor roles in human pulmonary sympathetic control pending translational studies.
Does sympathetic nerve stimulation affect pulmonary vascular tone via specific adrenoceptors in a feline model?
In the feline pulmonary vascular bed, neuronally released norepinephrine acts on alpha 1-, alpha 2-, and beta 2-adrenoceptors to produce a net biphasic pressure response.
Hyman et al. (1990) studied this question.
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