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June 1, 1986AJP Heart and Circulatory Physiology

Enhancement of alpha- and beta-adrenoceptor responses by elevations in vascular tone in pulmonary circulation

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Population

Feline pulmonary vascular bed model

Comparison

Intralobar injections of alpha 1-adrenoceptor… vs Same injections under resting tone conditions

Design

Preclinical

Authors

AHAlbert L. HymanTulane UniversityPKPhilip J. KadowitzMarquette University

Discussion

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Overview

Does not support changes in clinical management; leaves open translational relevance of tone-dependent adrenoceptor responses.

Structured PICO

P
Population
Feline pulmonary vascular bed model
I
Intervention
Intralobar injections of alpha 1-adrenoceptor agonists (phenylephrine, methoxamine), alpha 2-adrenoceptor agonists (UK 14304, B-HT 933), norepinephrine, epinephrine, and isoproterenol under elevated pulmonary vascular resistance
C
Comparator
Same injections under resting tone conditions
O
Outcome
Changes in lobar arterial pressure (vasoconstrictor and vasodilator responses)surrogate

Elevated vascular tone enhances both alpha-adrenoceptor-mediated vasoconstriction and beta-adrenoceptor-mediated vasodilation in the feline pulmonary vascular bed.

Cite This Study

Hyman et al. (1986) studied this question.

synapsesocial.com/papers/6a8798d786c445008eca805ahttps://doi.org/10.1152/ajpheart.1986.250.6.h1109
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of responses to sympathetic nerve stimulation in the feline pulmonary vascular bed1989 · 7 citations
  2. 2Analysis of pulmonary vascular responses in cats to sympathetic nerve stimulation under elevated tone conditions. Evidence that neuronally released norepinephrine acts on alpha 1-, alpha 2-, and beta 2-adrenoceptors.1990 · 15 citations
  3. 3Autonomic Regulation of the Pulmonary Circulation1985 · 18 citations
  4. 4Pulmonary vasodilator responses to vagal stimulation and acetylcholine in the cat.1983 · 62 citations
  5. 5Tone-dependent responses to acetylcholine in the feline pulmonary vascular bed1988 · 28 citations