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July 1, 1989Journal of Applied Physiology

Analysis of responses to sympathetic nerve stimulation in the feline pulmonary vascular bed

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Population

Feline pulmonary vascular bed model (cats)

Comparison

Sympathetic nerve stimulation in the presence of… vs Responses without specific antagonists or…

Design

Preclinical

Authors

AHAlbert L. HymanTulane UniversityPKPhilip J. KadowitzMarquette University

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Overview

Caution against clinical extrapolation from feline data; leaves open human adrenoceptor-targeted pulmonary hypertension research.

Structured PICO

P
Population
Feline pulmonary vascular bed model (cats)
I
Intervention
Sympathetic nerve stimulation in the presence of adrenergic receptor antagonists (prazosin, yohimbine, propranolol, ICI 118551)
C
Comparator
Responses without specific antagonists or baseline conditions
O
Outcome
Lobar vascular resistancesurrogate

This preclinical study demonstrates that sympathetic nerve stimulation in the feline pulmonary vascular bed represents a complex net effect of norepinephrine on alpha-1, alpha-2, and beta-2 adrenoceptors.

Cite This Study

Hyman et al. (1989) studied this question.

synapsesocial.com/papers/6a8736ff3f44447e627cc818https://doi.org/10.1152/jappl.1989.67.1.371
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of pulmonary vascular responses in cats to sympathetic nerve stimulation under elevated tone conditions. Evidence that neuronally released norepinephrine acts on alpha 1-, alpha 2-, and beta 2-adrenoceptors.1990 · 15 citations
  2. 2Enhancement of alpha- and beta-adrenoceptor responses by elevations in vascular tone in pulmonary circulation1986 · 34 citations
  3. 3Autonomic Regulation of the Pulmonary Circulation1985 · 18 citations
  4. 4Analysis of responses to serotonin in the pulmonary vascular bed of the cat1993 · 24 citations
  5. 5Presence of Postsynaptic α2-Adrenoreceptors of Predominantly Extrasynaptic Location in the Vascular Smooth Muscle of the Dog Hind Limb1980 · 140 citations