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January 1, 1985Journal of Cardiovascular Pharmacology

Autonomic Regulation of the Pulmonary Circulation

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Population

Feline pulmonary vascular bed model under conditions of controlled pulmonary blood flow and constant left…

Design

Preclinical

Authors

AHAlbert L. HymanTulane UniversityHLHoward LipptonTulane UniversityPKPhilip J. KadowitzMarquette University

Discussion

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Implication

Supports receptor-specific pulmonary vasoregulation in felines; leaves open translation to human pulmonary vascular disease.

Key Points

  • To evaluate pulmonary vascular responses to vagal stimulation, acetylcholine, sympathetic nerve stimulation, and various catecholamines in the feline pulmonary circulation.
  • Measured pulmonary vascular responses in a feline model under conditions of controlled pulmonary blood flow and constant left atrial pressure.
  • Administered acetylcholine, selective alpha-1 and alpha-2 agonists, and catecholamines (norepinephrine, dopamine, dobutamine) alongside nerve stimulation.
  • Vagal nerve stimulation dilates the pulmonary vascular bed via acetylcholine release acting on vascular muscarinic receptors.
  • Sympathetic nerve stimulation engages functional alpha- and beta 2-adrenoceptors, with selective alpha-1 and alpha-2 agonists mediating pulmonary vasoconstriction.
  • Pulmonary vascular responses to catecholamines reflect net alpha and beta activity, with dopamine producing greater alpha-vasoconstriction and dobutamine exerting greater beta-vasodilation.

Structured PICO

P
Population
Feline pulmonary vascular bed model under conditions of controlled pulmonary blood flow and constant left atrial pressure
I
Intervention
Vagal stimulation, acetylcholine, catecholamines, sympathetic nerve stimulation, selective alpha 1- and alpha 2-receptor agonists, norepinephrine, dopamine, and dobutamine
O
Outcome
Pulmonary vascular responses (vasodilation and vasoconstriction)surrogate

The feline pulmonary vascular bed is functionally innervated by both cholinergic and adrenergic nerves, with distinct receptor subtypes mediating vasodilation and vasoconstriction.

Cite This Study

Hyman et al. (1985) studied this question.

synapsesocial.com/papers/6a951af0c163d75667fa6ec6https://doi.org/10.1097/00005344-198500073-00010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pulmonary vasodilator responses to vagal stimulation and acetylcholine in the cat.1983 · 64 citations
  2. 2Enhancement of alpha- and beta-adrenoceptor responses by elevations in vascular tone in pulmonary circulation1986 · 34 citations
  3. 3Analysis of responses to sympathetic nerve stimulation in the feline pulmonary vascular bed1989 · 7 citations
  4. 4Analysis of pulmonary vascular responses in cats to sympathetic nerve stimulation under elevated tone conditions. Evidence that neuronally released norepinephrine acts on alpha 1-, alpha 2-, and beta 2-adrenoceptors.1990 · 15 citations
  5. 5Pulmonary vasodilator response to vagal stimulation is blocked by N omega-nitro-L-arginine methyl ester in the cat.1992 · 78 citations