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May 1, 1988Journal of Applied Physiology

Tone-dependent responses to acetylcholine in the feline pulmonary vascular bed

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Why the study?

Does acetylcholine affect lobar arterial pressure differently depending on baseline tone in the feline pulmonary vascular bed?

Population

Intact-chest cats (feline pulmonary vascular bed model)

Comparison

Intralobar injections of acetylcholine vs Responses under low-tone vs moderate-tone vs…

Design

Preclinical

Authors

AHAlbert L. HymanTulane UniversityPKPhilip J. KadowitzMarquette University

Discussion

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Implication

Feline pulmonary vascular responses to acetylcholine should not guide human care; leaves open receptor subtype roles in pulmonary hypertension.

Structured PICO

Does acetylcholine affect lobar arterial pressure differently depending on baseline tone in the feline pulmonary vascular bed?

P
Population
Intact-chest cats (feline pulmonary vascular bed model)
I
Intervention
Intralobar injections of acetylcholine
C
Comparator
Responses under low-tone vs moderate-tone (alveolar hypoxia) vs high-tone (U46619) conditions, with and without various antagonists (atropine, meclofenamate, BW 755C, pirenzepine, gallamine, pancuronium)
O
Outcome
Changes in lobar arterial pressuresurrogate

Pulmonary vascular responses to acetylcholine are tone-dependent, with low-tone vasoconstriction mediated by M1 receptors and high-tone vasodilation mediated by non-M1/non-M2 muscarinic receptors.

Cite This Study

Hyman et al. (1988) studied this question.

synapsesocial.com/papers/6a6f3f33e71d69abee07ecf1https://doi.org/10.1152/jappl.1988.64.5.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of tone on responses to acetylcholine in the rabbit pulmonary vascular bed1989 · 18 citations
  2. 2Pulmonary vasodilator responses to vagal stimulation and acetylcholine in the cat.1983 · 62 citations
  3. 3Enhancement of alpha- and beta-adrenoceptor responses by elevations in vascular tone in pulmonary circulation1986 · 34 citations
  4. 4Acetylcholine's effect on vascular resistance and compliance in the pulmonary circulation1989 · 28 citations
  5. 5Analysis of pulmonary vascular responses in cats to sympathetic nerve stimulation under elevated tone conditions. Evidence that neuronally released norepinephrine acts on alpha 1-, alpha 2-, and beta 2-adrenoceptors.1990 · 15 citations