Key result
In the feline pulmonary vascular bed, adenosine produces vasoconstriction at low baseline tone via A1 receptors and vasodilation at elevated tone via A2 receptors.
In a feline model, adenosine produces vasoconstriction at low baseline pulmonary vascular tone via A1 receptors and vasodilation at elevated tone via A2 receptors.
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Tone-dependent adenosine effects in feline lungs warrant caution before human translation; leaves open A1/A2 receptor targeting in pulmonary vascular disease.
Neely et al. (1996) studied Pulmonary vascular tone. Adenosine receptor agonists and antagonists was evaluated on Pulmonary vascular vasoconstriction and vasodilation responses. In the feline pulmonary vascular bed, adenosine produces vasoconstriction at low baseline tone via A1 receptors and vasodilation at elevated tone via A2 receptors.
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