Key result
Adenosine, NECA, and PIA caused dose-dependent vasodilation in isolated human pulmonary arteries (log EC30 -4.31, -4.31, and -3.53), mediated through A2 receptors on vascular smooth muscle.
Why the study?
Does adenosine induce vasodilation in isolated human pulmonary arteries and which receptors mediate this effect?
Does adenosine induce vasodilation in isolated human pulmonary arteries and which receptors mediate this effect?
Adenosine acts as a pulmonary vasodilator in humans via A2 receptors located on vascular smooth muscle, independent of the endothelium.
No takes yet. Share an insight, caveat, or question.
No immediate change to pulmonary hypertension care; extends A2 mediation data to human vessels but leaves open in vivo translation.
McCormack et al. (1989) studied this question. Adenosine, NECA, and PIA vs. 8-PT and endothelial denudation was evaluated on Dose-dependent vasodilation. Adenosine, NECA, and PIA caused dose-dependent vasodilation in isolated human pulmonary arteries (log EC30 -4.31, -4.31, and -3.53), mediated through A2 receptors on vascular smooth muscle.
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