Population
Isolated tissues (atria, aorta, and trachea) from guinea-pigs
Comparison
1,3-dipropyl-8-cyclopentylxanthine and… vs Responses to adenosine, carbachol, sodium…
Design
Preclinical
Authors
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Supports A1 selectivity in animal atria; leaves open translation to human adenosine receptor therapies.
The study demonstrates that CPX is an A1-selective adenosine receptor antagonist, supporting the classification of atrial adenosine receptors as A1 and aortic/tracheal receptors as A2.
Collis et al. (1989) studied this question.
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