Why the study?
Does methylene blue selectively inhibit pulmonary vasodilator responses in the feline pulmonary vascular bed?
Population
Feline pulmonary vascular bed (cats)
Comparison
Intralobar infusions of methylene blue vs U46619 infusion
Design
Preclinical
Authors
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No immediate clinical implications; extends support for cGMP-mediated pulmonary tone in animal models.
Does methylene blue selectively inhibit pulmonary vasodilator responses in the feline pulmonary vascular bed?
Methylene blue selectively inhibits endothelium-dependent and nitrogen oxide-containing vasodilators in the feline pulmonary vascular bed, supporting the role of cGMP in regulating pulmonary vascular tone.
Hyman et al. (1989) studied this question.
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