Population
Sprague-Dawley rats (320-420 g) and isolated rat aortic rings
Comparison
Methylene blue and nitric oxide synthase… vs Vehicle control
Design
Preclinical, Aortic rings were suspended randomly in separate organ baths
Follow-up
Up to 2 hours (acute observation)
Authors
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Should not yet inform clinical use of NO pathway modulators; leaves open whether L-NOARG pressor effects involve mechanisms beyond endothelial NO inhibition.
This preclinical study demonstrates that inhibition of endogenous NO biosynthesis does not necessarily lead to a pressor response in vivo, suggesting L-NOARG's pressor effects may involve mechanisms beyond endothelial NO inhibition.
Wang et al. (1995) studied this question.
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