Population
Isolated aorta rings and trachea from spontaneously hypertensive rats (SHR)
Design
Preclinical
Authors
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Questions methylene blue's specificity in EDCF studies; leaves open NO's role, requiring selective tools for confirmation.
The study demonstrates that NO does not chemically inactivate EDCF, and previous findings were confounded by the non-specific receptor antagonist effects of methylene blue.
Yang et al. (2004) studied this question.
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