Key result
In the renal artery of the rat, endothelium-dependent contractions are augmented by hypertension and facilitated by NOS inhibition and withdrawal of EDHF-mediated responses.
In rat renal arteries, hypertension augments endothelium-dependent contractions, which are further facilitated by NOS inhibition and the absence of EDHF-mediated responses.
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Supports investigation of endothelial pathways in hypertensive renal disease; leaves open clinical translation in humans.
Michel et al. (2008) studied Hypertension. Hypertension vs. Normotension (WKY rats) was evaluated on Endothelium-dependent contractions in renal arteries. In the renal artery of the rat, endothelium-dependent contractions are augmented by hypertension and facilitated by NOS inhibition and withdrawal of EDHF-mediated responses.
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