Why the study?
Endothelium-derived hyperpolarization regulates tone in smaller renal arteries and arterioles, but its significance in vivo in hypertension is unresolved.
Does acute intrarenal infusion of ACh alter renal blood flow and EDH-induced vasodilation differently in 12-week-old hypertensive versus normotensive rats?
Population
Isoflurane-anesthetized 12-week-old normo- and hypertensive rats
Comparison
Hypertensive rats vs normotensive rats during intrarenal ACh infusion and RVR modulation
Design
In vivo animal experimental study
Authors
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Renal EDH remains functional in early hypertension; leaves open whether α-adrenergic modulation enhances vasodilation in patients.
Does acute intrarenal infusion of ACh alter renal blood flow and EDH-induced vasodilation differently in 12-week-old hypertensive versus normotensive rats?
Renal endothelium-derived hyperpolarization remains functional in early hypertension in rats, and its vasodilatory effect is paradoxically enhanced by both activation and inhibition of α1-adrenergic receptors.
Stannov et al. (2019) studied this question.
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