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May 1, 1993AJP Heart and Circulatory Physiology

Mechanisms for altered endothelium-dependent vasorelaxation in isolated kidneys from experimental hypertensive rats

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Population

Isolated kidneys from spontaneously hypertensive rats, deoxycorticosterone acetate salt-hypertensive rats…

Comparison

Acetylcholine administration, high-K+ perfusion… vs Normotensive control rats

Design

Preclinical

Authors

HHHiroshi HayakawaMuseum of Natural and Environmental History, ShizuokaYHYoko HirataGifu UniversityESEmiko SuzukiRutgers, The State University of New Jersey

Discussion

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Overview

Different rat models implicate distinct endothelial factors; leaves open human hypertension subtype translation.

Structured PICO

P
Population
Isolated kidneys from spontaneously hypertensive rats (SHR), deoxycorticosterone acetate (DOCA) salt-hypertensive (DOCA salt) rats, and Dahl salt-sensitive (Dahl S) rats, and their normotensive controls (including Wistar-Kyoto rats [WKY]).
I
Intervention
Acetylcholine (ACh) administration, high-K+ perfusion, or pretreatment with glibenclamide
C
Comparator
Normotensive control rats
O
Outcome
Renal vascular resistance (RVR) and release rates of endothelium-derived relaxing factor (EDRF)surrogate

Attenuated endothelium-dependent vasorelaxation in hypertension is mediated by decreased EDHF in SHR, but by decreased EDRF in DOCA salt and Dahl S rats.

Cite This Study

Hayakawa et al. (1993) studied this question.

synapsesocial.com/papers/6a8adbc2e6afc07dcbf447b8https://doi.org/10.1152/ajpheart.1993.264.5.h1535
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Response to the Endothelium-Dependent Vasodilator Acetylcholine in Perfused Kidneys of Normotensive and Spontaneously Hypertensive Rats1993 · 13 citations
  2. 2Interactions between renal vascular resistance and endothelium‐derived hyperpolarization in hypertensive rats in vivo2019 · 5 citations
  3. 3Impaired Response to Acetylcholine Despite Intact Endothelium-Derived Relaxing Factor/Nitric Oxide in Isolated Microperfused Afferent Arterioles of the Spontaneously Hypertensive Rat1992 · 34 citations
  4. 4Impaired nitric oxide‐ and endothelium‐derived hyperpolarizing factor‐dependent dilation of renal afferent arteriole in Dahl salt‐sensitive rats2004 · 18 citations
  5. 5Role of endothelium in the response to endothelin in hypertension.1990 · 31 citations