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October 1, 2004Nephrology

Impaired nitric oxide‐ and endothelium‐derived hyperpolarizing factor‐dependent dilation of renal afferent arteriole in Dahl salt‐sensitive rats

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Why the study?

Does tempol improve impaired acetylcholine-induced afferent arteriolar dilation in Dahl salt-sensitive rats?

Population

Isolated perfused hydronephrotic kidneys from Dahl salt-sensitive and salt-resistant rats

Comparison

Acetylcholine following pretreatment with… vs Kidneys from Dahl salt-resistant rats; responses…

Design

Preclinical

Follow-up

8-10 weeks for chronic treatment

Authors

YOYuri OzawaTulane UniversityKHKôichi HayashiSt. Marianna University School of MedicineTKTakeshi KandaUniversity of Tsukuba

Discussion

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Overview

Suggests oxidative stress drives renal arteriolar impairment in salt-sensitive models; leaves open whether antioxidants benefit human hypertension.

Structured PICO

Does tempol improve impaired acetylcholine-induced afferent arteriolar dilation in Dahl salt-sensitive rats?

P
Population
Isolated perfused hydronephrotic kidneys from Dahl salt-sensitive and salt-resistant rats
I
Intervention
Acetylcholine (0.01-10 micromol/L) following pretreatment with indomethacin (100 micromol/L) with or without nitro-l-arginine methylester (100 micromol/L), and treatment with the antioxidant tempol (chronic for 8-10 weeks or acute)
C
Comparator
Kidneys from Dahl salt-resistant rats; responses without tempol treatment
O
Outcome
Reversal of noradrenaline (0.3 micromol/L)-induced constriction (vasodilation) of afferent arteriolessurrogate

In Dahl salt-sensitive rats, impaired nitric oxide- and EDHF-mediated renal afferent arteriolar vasodilation is partially driven by enhanced free radical activity, which can be reversed by the antioxidant tempol.

Cite This Study

Ozawa et al. (2004) studied this question.

synapsesocial.com/papers/6a891112cd9902a7ca1271b0https://doi.org/10.1111/j.1440-1797.2004.00292.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impaired activities of antioxidant enzymes elicit endothelial dysfunction in spontaneous hypertensive rats despite enhanced vascular nitric oxide generation2003 · 153 citations
  2. 2Oxidative Stress in Dahl Salt-Sensitive Hypertension2003 · 169 citations
  3. 3Impaired Nitric Oxide-Independent Dilation of Renal Afferent Arterioles in Spontaneously Hypertensive Rats.1999 · 17 citations
  4. 4Cytochrome P450 Activity and Endothelial Dysfunction in Insulin Resistance2000 · 39 citations
  5. 5Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress2000 · 3,837 citations