Why the study?
Does salt-induced hypertension alter the influence of endogenous nitric oxide on resting microvascular tone in Dahl salt-sensitive rats?
Does salt-induced hypertension alter the influence of endogenous nitric oxide on resting microvascular tone in Dahl salt-sensitive rats?
Basal release of nitric oxide normally influences arteriolar tone in skeletal muscle of Dahl salt-sensitive rats, but this influence is suppressed in established salt-induced hypertension without generalized impairment of endothelial function.
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Caution against clinical extrapolation; leaves open whether basal NO tone is suppressed in human salt-sensitive hypertension.
Matthew A. Boegehold (1992) studied this question.
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