Key result
In Dahl salt-resistant rats on high sodium intake, nNOS inhibition with 7NI increased mean arterial pressure to 120% of control compared to 98% with high sodium alone (P<0.05).
Why the study?
Does nNOS inhibition with 7NI affect arterial pressure and renal hemodynamics in Dahl salt-resistant and salt-sensitive rats on varying sodium intakes?
Population
53 Dahl salt-resistant and salt-sensitive rats/Rapp strain of 7 to 8 weeks of age with indwelling arterial…
Comparison
Intravenous 7-nitroindazole for 5 days vs Vehicle infusion
Design
Preclinical
Follow-up
5 days
Authors
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nNOS findings in Dahl rats are hypothesis-generating; leaves open relevance to human salt-sensitive hypertension.
Does nNOS inhibition with 7NI affect arterial pressure and renal hemodynamics in Dahl salt-resistant and salt-sensitive rats on varying sodium intakes?
Absolute Event Rate: 120% vs 98%
p-value: p=<0.05
Inhibition of nNOS causes salt-sensitive hypertension in normally salt-resistant Dahl rats, suggesting nNOS plays a protective role against salt-sensitivity.
Tan et al. (1999) studied Dahl salt-sensitive hypertension (n=53). 7-nitroindazole (7NI) vs. vehicle infusion / high Na alone was evaluated on mean arterial pressure (% control) (p=<0.05). In Dahl salt-resistant rats on high sodium intake, nNOS inhibition with 7NI increased mean arterial pressure to 120% of control compared to 98% with high sodium alone (P<0.05).
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