Key result
Intramedullary aminoguanidine increased mean arterial pressure to 132% of control vs 121% with high sodium alone in salt-sensitive rats (P<0.05), showing iNOS blunts pressure increases.
Why the study?
Does selective iNOS inhibition with aminoguanidine increase arterial pressure in Dahl salt-sensitive and salt-resistant rats on high sodium intake?
Population
40 Dahl/Rapp salt-resistant and salt-sensitive rats, equipped with indwelling arterial, venous, and renal…
Comparison
Selective iNOS inhibition with continuous… vs High Na intake alone
Design
Preclinical
Follow-up
5 days
Authors
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May implicate renal medullary iNOS in rat salt sensitivity; leaves open human therapeutic relevance.
Does selective iNOS inhibition with aminoguanidine increase arterial pressure in Dahl salt-sensitive and salt-resistant rats on high sodium intake?
Absolute Event Rate: 132% vs 121%
p-value: p=< 0.05
Renal medullary iNOS-derived nitric oxide helps prevent excessive increases in arterial pressure during high sodium intake in Dahl salt-sensitive rats.
Tian et al. (2003) studied Salt-sensitive hypertension (n=40). Aminoguanidine (AG) via continuous intravenous or renal medullary interstitial infusion vs. High Na intake alone was evaluated on Mean arterial pressure (% of control) (p=< 0.05). Intramedullary aminoguanidine increased mean arterial pressure to 132% of control vs 121% with high sodium alone in salt-sensitive rats (P<0.05), showing iNOS blunts pressure increases.
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