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December 1, 2000AJP Regulatory Integrative and Comparative Physiology

Mechanisms of salt-sensitive hypertension: role of inducible nitric oxide synthase

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Why the study?

Does selective iNOS inhibition with aminoguanidine alter arterial pressure and renal hemodynamics in Dahl salt-resistant and salt-sensitive rats on varying sodium intakes?

Population

32 Dahl/Rapp salt-resistant and salt-sensitive rats equipped with indwelling arterial and venous catheters

Comparison

Intravenous aminoguanidine for 5 days during low… vs Low or high sodium intake alone without…

Design

Preclinical

Follow-up

5 days

Authors

DTDunyong Y. TanShenZhen People’s HospitalSMShumei MengKennedy Krieger InstituteGCGarrick W. CasonUniversity of Tennessee at Chattanooga

Discussion

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Implication

iNOS inhibition raises MAP on high-salt diet in Dahl rats; supports protective role of iNOS-derived NO but leaves open human relevance.

Structured PICO

Does selective iNOS inhibition with aminoguanidine alter arterial pressure and renal hemodynamics in Dahl salt-resistant and salt-sensitive rats on varying sodium intakes?

P
Population
32 Dahl/Rapp salt-resistant (R) and salt-sensitive (S) rats equipped with indwelling arterial and venous catheters
I
Intervention
Intravenous aminoguanidine (AG, 12.3 mg/kg/h) for 5 days during low (0.87 mmol/day) or high (20.6 mmol/day) sodium intake
C
Comparator
Low or high sodium intake alone without aminoguanidine
O
Outcome
Changes in mean arterial pressuresurrogate

Nitric oxide produced by iNOS helps prevent salt-sensitive hypertension in Dahl salt-resistant rats and decreases salt sensitivity in Dahl salt-sensitive rats.

Cite This Study

Tan et al. (2000) studied this question.

synapsesocial.com/papers/6a892e96f65c7b03f94d2a9ehttps://doi.org/10.1152/ajpregu.2000.279.6.r2297

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of nitric oxide in regulation of long-term pressure-natriuresis relationship in Dahl rats1995 · 108 citations
  2. 2Role of Neuronal Nitric Oxide Synthase in Dahl Salt-Sensitive Hypertension1999 · 56 citations
  3. 3Inducible Nitric Oxide Synthase and Blood Pressure1998 · 85 citations
  4. 4Nitric Oxide Synthase Isoform Activities in Kidney of Dahl Salt-Sensitive Rats1995 · 59 citations
  5. 5Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition1999 · 42 citations