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March 1, 2001American Journal of HypertensionOpen Access

The role of nitric oxide and the renin-angiotensin system in salt-restricted Dahl rats

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Why the study?

Does chronic NO inhibition with L-NA increase blood pressure and induce renal injury in salt-restricted Dahl salt-sensitive rats compared to salt-resistant rats?

Population

Male Dahl-Iwai salt-sensitive (DS) and salt-resistant (DR) rats (6 weeks old) fed with a low-salt (0.3%) diet

Comparison

NG-nitro-L-arginine administered for 5 weeks vs Dahl salt-resistant rats receiving the same…

Design

Preclinical

Follow-up

5 weeks

Authors

HKHitomi KataokaYamagata University

Discussion

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Implication

NO depletion may worsen hypertension and renal injury in salt-sensitive models despite restriction; leaves open human translation and RAS mechanisms.

Structured PICO

Does chronic NO inhibition with L-NA increase blood pressure and induce renal injury in salt-restricted Dahl salt-sensitive rats compared to salt-resistant rats?

P
Population
Male Dahl-Iwai salt-sensitive (DS) and salt-resistant (DR) rats (6 weeks old) fed with a low-salt (0.3%) diet
I
Intervention
NG-nitro-L-arginine (L-NA; dissolved in 60 mg/L deionized water) administered for 5 weeks
C
Comparator
Dahl salt-resistant (DR) rats receiving the same treatment
O
Outcome
Pressor responses (systolic blood pressure) and renal histologic changessurrogate

Endogenous nitric oxide depletion participates in the development of hypertension and glomerular injury in Dahl salt-sensitive rats through potential RAS activation, even under sodium restriction.

Cite This Study

Hitomi Kataoka (2001) studied this question.

synapsesocial.com/papers/6a8425f760b15e9f17c51c8ahttps://doi.org/10.1016/s0895-7061(00)01255-3

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of chronic NO synthase inhibition in rats on renin-angiotensin system and sympathetic nervous system1995 · 86 citations
  2. 2Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.1992 · 794 citations
  3. 3Angiotensin II receptor antagonist delays renal damage and stroke in salt-loaded Dahl salt-sensitive rats1992 · 77 citations
  4. 4NG-monomethyl-L-arginine and nitroarginine potentiate pressor responsiveness of vasoconstrictors in conscious rats1992 · 61 citations
  5. 5Salt Induces Vascular AT<sub>1</sub>Receptor Overexpression In Vitro and In Vivo1998 · 106 citations