Why the study?
Does nitric oxide synthase inhibition with L-NAME induce salt-sensitive hypertension and alter angiotensin II regulation in male Wistar-Kyoto rats?
Does nitric oxide synthase inhibition with L-NAME induce salt-sensitive hypertension and alter angiotensin II regulation in male Wistar-Kyoto rats?
Nitric oxide synthase inhibition with L-NAME induces a salt-sensitive increase in blood pressure in rats that appears to be dependent on angiotensin II.
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Highlights potential Ang II dependence of salt-sensitive hypertension during NOS inhibition in rats; leaves open relevance to human salt sensitivity.
Hodge et al. (2002) studied this question.
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