Why the study?
Does L-NAME administration alter the renin-angiotensin system in Dahl salt-sensitive and salt-resistant rats?
Population
Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats fed a 0.3% NaCl or 8% NaCl diet
Comparison
NG-nitro-L-arginine methyl ester 12-18 mg/kg per… vs Vehicle (water)
Design
Preclinical
Follow-up
1 week
Authors
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Suggests nitric oxide inhibits renin in high-salt Dahl salt-sensitive rats; leaves open translation to human hypertension.
Does L-NAME administration alter the renin-angiotensin system in Dahl salt-sensitive and salt-resistant rats?
Nitric oxide appears to have an inhibitory role on renin release in Dahl salt-sensitive rats fed a high-salt diet.
Kasuya et al. (1999) studied this question.
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