Key result
Continuous intravenous infusion of L-arginine prevented changes in the pressure-natriuresis relationship and the development of salt-induced hypertension in Dahl salt-sensitive rats.
Why the study?
Does L-arginine infusion prevent salt-induced hypertension and changes in the pressure-natriuresis relationship in salt-sensitive Dahl rats?
Population
6- to 7-week-old conscious salt-sensitive and salt-resistant Brookhaven strain Dahl rats with indwelling…
Comparison
L-arginine infused intravenously at 2 or 4… vs Control salt-resistant rats and untreated…
Design
Preclinical
Follow-up
16 days
Authors
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Impaired NO in salt-sensitive rats should not guide therapy; leaves open translational relevance to human hypertension.
Does L-arginine infusion prevent salt-induced hypertension and changes in the pressure-natriuresis relationship in salt-sensitive Dahl rats?
Hu et al. (1995) studied Salt-induced hypertension. L-arginine vs. Control R rats / untreated S rats was evaluated on Whole body NO production, long-term pressure-natriuresis relationship, and arterial pressure. Continuous intravenous infusion of L-arginine prevented changes in the pressure-natriuresis relationship and the development of salt-induced hypertension in Dahl salt-sensitive rats.
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