Key result
Long-term L-arginine administration normalized pressure-natriuretic responses and lowered mean arterial pressure (127 vs 158 mm Hg) in salt-sensitive rats on a high-sodium diet.
Why the study?
Does L-arginine administration normalize pressure natriuresis in hypertensive Dahl salt-sensitive rats?
Population
Dahl salt-sensitive rats on an 8% sodium diet, with identically treated salt-resistant rats serving as…
Comparison
L-arginine administered daily for 3 weeks or… vs Vehicle administered daily for 3 weeks.
Design
Preclinical
Follow-up
3 weeks
Authors
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No role in clinical hypertension management; leaves open translation of L-arginine effects from salt-sensitive rat models.
Does L-arginine administration normalize pressure natriuresis in hypertensive Dahl salt-sensitive rats?
p-value: p=<.05
Long-term L-arginine administration normalizes pressure-natriuretic responses in salt-sensitive rats, an effect that is specific to the salt-sensitive strain and not due to the prevention of renal damage.
Patel et al. (1993) studied Hypertension. L-arginine vs. vehicle was evaluated on Pressure-natriuretic response (p=<.05). Long-term L-arginine administration normalized pressure-natriuretic responses and lowered mean arterial pressure (127 vs 158 mm Hg) in salt-sensitive rats on a high-sodium diet.
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