Why the study?
Does renal medullary interstitial infusion of L-arginine prevent high-salt-induced hypertension in Dahl salt-sensitive rats?
Does renal medullary interstitial infusion of L-arginine prevent high-salt-induced hypertension in Dahl salt-sensitive rats?
Renal medullary infusion of L-arginine prevents salt-induced hypertension in Dahl salt-sensitive rats, indicating that salt sensitivity may be due to a deficit of medullary substrate availability and NO production.
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Supports medullary L-arginine/NO role in experimental salt sensitivity; hypothesis-generating with no clinical implications yet.
Miyata et al. (1998) studied this question.
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