Why the study?
Does L-arginine supplementation improve regional blood flow and renal hemodynamics in Dahl-Iwai salt-sensitive rats on a high-salt diet?
Population
Male 6-week-old Dahl-Iwai salt-sensitive rats and Dahl-Iwai salt-resistant rats maintained on an 8% NaCl…
Comparison
Tap water containing L-arginine at a… vs Tap water without L-arginine
Design
Preclinical
Follow-up
4 weeks
Authors
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Hypothesis-generating for L-arginine in salt-sensitive hypertension models; clinical translation remains untested.
Does L-arginine supplementation improve regional blood flow and renal hemodynamics in Dahl-Iwai salt-sensitive rats on a high-salt diet?
L-arginine supplementation normalizes renal hemodynamics and suppresses proteinuria in salt-sensitive hypertensive rats, suggesting a role for nitric oxide in salt-induced hypertension.
Hong He (1997) studied this question.
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