Key result
Decreased nitric oxide production, particularly by neuronal nitric oxide synthase, plays a major role in the development of salt-sensitive hypertension in humans and animal models.
Population
Humans with salt-sensitive hypertension and Dahl salt-sensitive (S) and salt-resistant (R) rats
Design
Review
Authors
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Should not yet alter clinical practice; hypothesis-generating for neuronal NOS-targeted interventions in salt-sensitive hypertension.
Deficient nitric oxide production, particularly by neuronal NOS, plays a major mechanistic role in the development of salt-sensitive hypertension.
R. Davis Manning (2001) conducted a review in Salt-sensitive hypertension. Nitric oxide (NO) system was evaluated. Decreased nitric oxide production, particularly by neuronal nitric oxide synthase, plays a major role in the development of salt-sensitive hypertension in humans and animal models.
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