Key result
In Dahl salt-sensitive rats, the central sympathetic inhibitory system mediated by nNOS neurons is upregulated as a compensatory response to hypertension, keeping resting peripheral sympathetic nerve activity at levels similar to normotensive rats.
This review highlights that in salt-sensitive hypertension, an nNOS-mediated central inhibitory system is upregulated to counteract sympathetic hyper-reactivity, explaining why resting peripheral sympathetic nerve activity may not appear elevated.
Supports nNOS compensation in rat salt-sensitive hypertension models; leaves open translation to human sympathetic regulation or therapy.
In essential hypertension, peripheral sympathetic nerve activity is generally thought to be increased regardless of salt sensitivity or insensitivity. Recent reports suggest that the cause may be abnormal central nervous system enhancement. However, other several reports have shown that a central sympathetic inhibitory system, the neuronal nitric oxide synthase system, may be strongly enhanced in salt-sensitive hypertensive Dahl rats, an animal model of salt-sensitive hypertension. These two facts lead to questions what happens finally in peripheral sympathetic activity and what is the relationship between sympathetic nerves and hypertension. In this review, we will show evidences for enhancement of central sympathetic inhibitory system, putative cause for up-regulation of central neuronal nitric oxide synthase system, and a role of its function, then lastly we consider the relationship between hypertension and sympathetic nerves in a rat model, with a focus on salt-sensitive hypertension.
No takes yet. Share an insight, caveat, or question.
Yasuhiro Nishida (2013) conducted a review in Salt-sensitive hypertension. High salt diet and nNOS inhibitors vs. Low salt diet / vehicle was evaluated. In Dahl salt-sensitive rats, the central sympathetic inhibitory system mediated by nNOS neurons is upregulated as a compensatory response to hypertension, keeping resting peripheral sympathetic nerve activity at levels similar to normotensive rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: