January 1, 1993Journal of Cardiovascular Pharmacology
Endothelium-Dependent Contractions to Endothelin in the Rat Aorta Are Mediated by Thromboxane A2
Population
Aortic rings from spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats
Comparison
Endothelin-1 and endothelin-3 exposure, with and… vs Aortic rings without endothelium; WKY rats vs SHRs
Design
Preclinical
Authors
Discussion
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Implication
Suggests thromboxane A2 role in hypertensive vascular dysfunction; leaves open translation to human hypertension or therapy.
Structured PICO
P
Population
Aortic rings from spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats
I
Intervention
Endothelin-1 (ET-1) and endothelin-3 (ET-3) exposure, with and without inhibitors (indomethacin, dazoxiben, SQ 29,548)
C
Comparator
Aortic rings without endothelium; WKY rats vs SHRs
O
Outcome
Isometric tension (contractions) and release of thromboxane B2surrogate
Endothelium-dependent contractions to endothelin in spontaneously hypertensive rats are mediated by thromboxane A2, highlighting a mechanism of vascular dysfunction in hypertension.
Cite This Study
Taddei et al. (1993) studied this question.