Population
Aortas from spontaneously hypertensive rats (SHR) and normotensive controls (WKY)
Comparison
Endothelin-1 exposure in organ chambers vs Normotensive controls and rings without…
Design
Preclinical
Authors
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Hypothesis-generating in hypertensive rat models; leaves open relevance to human vascular pathophysiology or therapy.
In spontaneously hypertensive rats, vascular smooth muscle contractions to endothelin are reduced, and endothelin may stimulate the release of an indomethacin-sensitive endothelium-derived contracting factor.
Auch–Schwelk et al. (1992) studied this question.
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