Population
Aortic rings from spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Endothelin-1 with or without inhibitors vs Aortic rings without endothelium, and WKY rats…
Design
Preclinical
Authors
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No immediate clinical implications from this animal model; leaves open whether prostaglandin H2 pathways extend to human hypertension therapies.
Endothelin-1 induces the release of prostaglandin H2 from endothelial cells, which modulates vasoconstriction, particularly in hypertensive states.
Asano et al. (1994) studied this question.
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